EpimiRNA-hosted workshop at 11th European Congress on Epileptology
Professors Henshall and Rosenow hosted a very lively and well-attended Forum on miRNA in epilepsy on July 3rd as part of the 11th ECE, held in Stockholm, Sweden. The ECE is a bi-annual premier meeting that attracts basic scientists and clinical epileptologists from all over Europe. The purpose of the forum was to bring together researchers to share the latest discoveries on microRNA in epilepsy, discuss technical challenges, promote sharing of knowledge and resources, and help to identify new collaborations, including with industry. The Forum featured a number of leading researchers from within EpimiRNA as well as outside. In the first part of the Forum, David Henshall presented unpublished data on new miRNAs identified through profiling brain and biofluids, with a particular focus on ion channels as targets. Next, Jan Gorter (Amsterdam) presented miRNA profiling findings from different hippocampal regions after status epilepticus and during different phases of epilepsy development. Gorter also presented data on blood profiles of three miRNA. Eleonora Aronica (also Amsterdam) presented on an inflammation-linked miRNA (miR-146a) in human and experimental epilepsy and finally Annamaria Vezzani (Milan) presented work showing anti-epileptic effects of overexpressing miR-146a in vivo. Felix Rosenow next outlined why there is a clinical need for biomarkers in epilepsy and presented preliminary data from microRNA profiling in patients with epilepsy. Finally, Gianpiero Cavalleri (Dublin) presented an overview of the planned analysis of over 1000 epilepsy patients in EpimiRNA and the progress on sequencing made to date. Finally, the session closed with Q & A from the Forum members and audience.