EpimiRNA
Bicoll © Kai Lamottke
Bicoll © Kai Lamottke

Partner 3 - University of Utrecht - UMCU

 

Jeroen Pasterkamp

Prof. Jeroen Pasterkamp

Principal Investigator

Phone: +31 88 7568831

Fax: +31 88 7569032

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UMC Utrecht

Universteitsweg 100

3584 CG Utrecht

The Netherlands

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EpimiRNA Team UMCU

 

Dr. Guliano Guliani

Postdoctoral Fellow 

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Dr. Pierre De Graan

Principal Investigator

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Mrs. Marina De Wit

Research Technician

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Dr. Vangoor Vamshidhar

Postdoctoral Fellow 

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Institute presentation

The focus of our laboratory is directed towards understanding 1) the signaling events and molecular mechanisms involved in the formation of neuronal connections during development, and 2) the molecular mechanisms underlying changes in or loss of neuronal connectivity during neurological disease (in particular epilepsy). Our investigations concentrate on mouse and humanized cell models (iPS) using an integrated approach involving molecular cell biology, neuroanatomy, (in vivo) functional proteomics, imaging, HC screening, and mouse genetics. We are performing genome-wide miRNA screens in patient-derived brain material and genome functional screens using miRNA libraries to dissect the role and mechanism-of-action of miRNAs in the developing and diseased nervous system, with an emphasis on a role for miRNAs in regulating neuronal connectivity. Functional studies of miRNAs (reporter assays, knockdown/overexpression in neurons (in culture and in vivo), neuronal connectivity, target finding) in the normal situation and during epileptogenesis using molecular, cell biological and mouse genetic approaches. High-throughput microscopy screens in neurons using lentiviral miRNA libraries. Genome wide miRNA profiling of human patient material.

EpimiRNA Team

EpimiRNA Work packages

EpimiRNA Work packages
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Great success of the EpimiRNA consortium resulting in EMBO publication!

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