Bicoll © Kai Lamottke
Bicoll © Kai Lamottke
Bicoll © Kai Lamottke

Work packages

 

  • The Main aims of the EpimiRNA consortium are to
    • Identify miRNAs that are functional in human TLE and evaluate how non-pharmacological interventions including brain stimulation modulate miRNAs
    • Identify miRNAs involved in epileptogenesis and determine the mechanism(s) by which miRNA changes contribute to epileptogenesis
    • Determine the role of genetic variation in miRNAs and their biogenesis pathway in human TLE
    • Identify miRNAs that are biomarkers of epileptogenesis or seizures in humans
    • Develop novel miRNA-modulating molecules as future therapeutics for epilepsy

 

 

EpimiRNA Workpackages MicroRNA signature of experimental epileptogenesis MicroRNA signature of human temporal lobe epilepsy MicroRNA in the therapeutic efficacy of brain stimulation MiRNA mechanisms of epileptogenesis miRNA genetic variation in human epilepsy Integrated miRNA bioinformatics for understanding epileptogenesis and biomarker identification Systems Biology Integration and Multiple-Scale Modelling of miRNA to Understand Epileptogenesis miRNA-Based Therapeutics for Epilepsy New miRNA-Modulating Chemical Entities for the Treatment of Epilepsy Dissemination, Training & Exploitation Project management

Work package Leads

EpimiRNA PERT chart WP1: MicroRNA signature of experimental epileptogenesis (RCSI) WP11: Project management (GABO:mi) WP7: Systems Biology Integration and Multiple-Scale Modelling of miRNA (RCSI) WP2: MicroRNA signature of human temporal lobe epilepsy (UKER) WP3: MicroRNA in the therapeutic efficacy of brain stimulation (UNIMAR) WP4: MiRNA mechanisms of epileptogenesis (UMCU) WP5: MiRNA genetic variation in human epilepsy (CU) WP6: Integrated miRNA bioinformatics (AU) WP8: MiRNA-Based Therapeutics for Epilepsy (UCL) WP9: New miRNA-Modulating Chemical Entities for the Treatment of Epilepsy (Bicoll)

EpimiRNA Team

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Great success of the EpimiRNA consortium resulting in EMBO publication!

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